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From the following article

Stochastic kinetics of intracellular huntingtin aggregate formation

David W Colby, John P Cassady, Grace C Lin, Vernon M Ingram & K Dane Wittrup

Nature Chemical Biology 2, 319 - 323 (2006) Published online: 14 May 2006

doi:10.1038/nchembio792

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Figure 1 - Unfortunately we are unable to provide accessible alternative text for this. If you require assistance to access this image, or to obtain a text description, please contact npg@nature.com

Figure 1

Hypothesized mechanism of httex1 aggregate formation3 (Models 1, 1a and 1b in Supplementary Methods).

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Figure 2

FACS sorting and fluorescence microscopy of cell populations were used to determine rates of aggregate formation.

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Figure 3

Rate of httex1-GFP aggregate formation as a function of time, concentration and polyglutamine length.

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Figure 4

Simulated fraction of neurons that do not experience an aggregate nucleation event as a function of concentration (10, 30, 100 or 300 nM) and age for httex1Q47, based on Model 1a or 2, and assuming neurons of volume equivalent to cultured ST14A cells.

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