Figure 3 - Rate of httex1-GFP aggregate formation as a function of time, concentration and polyglutamine length.
From the following article
Stochastic kinetics of intracellular huntingtin aggregate formation
David W Colby, John P Cassady, Grace C Lin, Vernon M Ingram & K Dane Wittrup
Nature Chemical Biology 2, 319 - 323 (2006) Published online: 14 May 2006
doi:10.1038/nchembio792
(a) Natural log of the fraction of cells not containing aggregates as a function of time (time after FACS sorting is shown on graph), showing exponential decline. (b) Concentration-dependence of the rate constant 
for aggregate formation. The form of the nucleation rate constant for each of the models under consideration is as follows: =VcellNAk+Kn*C2httex1 (Model 1a); =VcellNAkmisfoldC2httex1 (Model 1b); =VcellNAk+Kn*2C2httex1 (Model 2). The solid line is the least-squares fit to the leading constant for a second-order concentration-dependence ( = 
Chttex12; Models 1a and 2). The dotted line is the least-squares fit to a first-order concentration-dependence ( = 
Chttex1; Model 1b). Error bars denote 95% confidence intervals, n = 95 cells on average for each point in a, n = 647 cells on average for each point in b.
