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Site-specific PEGylation of native disulfide bonds in therapeutic proteins

Sunil Shaunak, Antony Godwin, Ji-Won Choi, Sibu Balan, Elisa Pedone, Damotharan Vijayarangam, Sibylle Heidelberger, Ian Teo, Mire Zloh & Steve Brocchini

Nature Chemical Biology 2, 312 - 313 (2006) Published online: 23 April 2006

doi:10.1038/nchembio786

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Figure 1

Structural characterization.

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Figure 2

Biological activities.

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