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Nature Chemical Biology 2, 300 - 301 (2006)
doi:10.1038/nchembio0606-300
Chemical knockout of C-reactive protein in cardiovascular disease
Jay W Heinecke1
- Jay W. Heinecke is in the Department of Medicine, University of Washington School of Medicine, Box 356426, Seattle, Washington 98195, USA. e-mail: heinecke@u.washington.edu
Abstract
Human C-reactive protein (CRP) has been implicated in the inflammatory responses associated with heart attacks and strokes. A small-molecule inhibitor of CRP limits myocardial infarction in rats and should facilitate mechanistic studies of cardiovascular disease.
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