News and Views
Nature Chemical Biology 2, 297 - 298 (2006)
doi:10.1038/nchembio0606-297
Nucleation of huntingtin aggregation in cells
Ronald Wetzel1
- Ronald Wetzel is in the Graduate School of Medicine, University of Tennessee, Knoxville, Tennessee 37920, USA. e-mail: rwetzel@mc.utmck.edu
Abstract
In diseases linked to protein aggregation, the initiation of aggregation can be a critical point in the disease mechanism. New studies in cells expressing huntingtin exon I suggest that the initiation of polyglutamine aggregation proceeds by a simple nucleation mechanism.
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