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Nature Chemical Biology 2, 295 - 296 (2006)
doi:10.1038/nchembio0606-295
Signalomic signatures enlighten drug profiling
Robert T Abraham1
- Robert T. Abraham is in the Department of Oncology Discovery, Wyeth, 401 N. Middletown Road, Pearl River, New York 10965, USA. e-mail: abrahar@wyeth.com.
Abstract
When introduced into living cells, drugs frequently evoke unanticipated responses that are due either to off-target effects or to previously unknown interactions between the intended target and other biochemical pathways. The development of a panel of high-resolution sentinel assays for signal-transduction cascades in human cells promises to enhance the power of chemical genetics and increase the efficiency of drug-discovery research.
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RESEARCH
Identifying off-target effects and hidden phenotypes of drugs in human cellsNature Chemical Biology Article (01 Jun 2006)

