Commentary
Nature Chemical Biology 2, 284 - 287 (2006)
doi:10.1038/nchembio0606-284
Making carbon-nitrogen bonds in biological and chemical synthesis
- Ryan Hili and Andrei K. Yudin are at the Davenport Research Laboratories, Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, Ontario M5S 3H6, Canada. e-mail: ayudin@chem.utoronto.ca
Abstract
The function of many biologically active molecules requires the presence of carbon-nitrogen bonds in strategic positions. The biosynthetic pathways leading to such bonds can be bypassed through chemical synthesis to synthesize natural products more efficiently and also to generate the molecular diversity unavailable in nature.
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