Supplementary information
From the following article
Daryl A Bosco, Douglas M Fowler, Qinghai Zhang, Jorge Nieva, Evan T Powers, Paul Wentworth, Jr, Richard A Lerner & Jeffery W Kelly
Nature Chemical Biology 2, 249 - 253 (2006) Published online: 26 March 2006 Corrected online: 8 May 2006
doi:10.1038/nchembio782
Supplementary Fig. 1
Addition of cholesterol metabolites (2/3) and (4) is toxic to SHSY5Y cells, whereas cholesterol is not toxic.
Supplementary Fig. 2
Electron microscopy (EM) images for control 
S aggregation reactions.
Supplementary Fig. 3
S catalyzes the conversion of oxidative metabolite (2) into (3) as measured by thin layer chromatography (TLC).
Supplementary Fig. 4
The hastening of S fibrilization by (4) is not affected by addition of the competitive Schiff-base inhibitor aminoguanidine.
Supplementary Table 1
Summary of the temporal biophysical characterization of oxidative cholesterol metabolite hastened S fibrilization.
Supplementary Methods
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