News and Views
Nature Chemical Biology 2, 234 - 235 (2006)
doi:10.1038/nchembio0506-234
Redox sensing and histidine oxidation: no longer PerR-fect strangers
W Scott Moye-Rowley1
- W. Scott Moye-Rowley is in the Department of Physiology and Biophysics, University of Iowa, Iowa City, Iowa 52242, USA. e-mail: scott-moye-rowley@uiowa.edu
Abstract
Oxidation of cysteine residues is a well-described means of sensing oxidative stress. Analysis of a bacterial transcriptional repressor protein indicates that metal-catalyzed oxidation of histidine residues can provide oxidative stress control in a cysteine-independent fashion.
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