1. W. Scott Moye-Rowley is in the Department of Physiology and Biophysics, University of Iowa, Iowa City, Iowa 52242, USA. e-mail: scott-moye-rowley@uiowa.edu

Abstract

Oxidation of cysteine residues is a well-described means of sensing oxidative stress. Analysis of a bacterial transcriptional repressor protein indicates that metal-catalyzed oxidation of histidine residues can provide oxidative stress control in a cysteine-independent fashion.

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