1. John E. Cronan is in the Department of Microbiology and Biochemistry, University of Illinois, B103 CLSL, 601 S. Goodwin Ave., Urbana, Illinois 61801, USA. e-mail: j-cronan@life.uiuc.edu.

Abstract

The crystal structures of two chain-building megasynthases, the fatty acid synthases of mammals and fungi, have recently been reported. Although both are composed of modules derived from the discrete enzymes that catalyze bacterial fatty acid synthesis, the two synthases have dramatically different architectures.

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