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Nature Chemical Biology 2, 231 - 232 (2006)
doi:10.1038/nchembio0506-231
A library of RNA bridges
- Ning Gao and Joachim Frank are in the Department of Biomedical Sciences, State University of New York at Albany, and the Howard Hughes Medical Institute, Health Research, Inc., Wadsworth Center, Empire State Plaza, Albany, New York 12201-0509, USA. e-mail: joachim@wadsworth.org.
Abstract
Translation starts with the assembly of the ribosome from its subunits, which requires the formation of intersubunit bridges. A combinatorial mutagenesis approach has now identified a number of the 16S rRNA residues involved in intersubunit bridging that are functionally important for the ribosome.
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