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Nature Chemical Biology 2, 229 - 230 (2006)
doi:10.1038/nchembio0506-229
Metalloproteases see the light
Matthew Bogyo1
- Matthew Bogyo is in the Departments of Pathology and Microbiology and Immunology, Stanford University, 300 Pasteur Drive, Stanford, California 94305, USA. e-mail: mbogyo@stanford.edu
Abstract
Small-molecule probes that chemically tag targets by virtue of their enzymatic activities offer a means to focus system-wide experiments and provide functional information for entire families of proteins. Recent advances in the design and application of light-activated probes that target metalloproteases have created the opportunity to study this medically important family of enzymes in unprecedented detail.
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