Commentary
Nature Chemical Biology 2, 224 - 227 (2006)
doi:10.1038/nchembio0506-224
The integration of cell and chemical biology in protein folding
Jeffery W Kelly1 & William E Balch1
- Jeffery W. Kelly is at the Department of Chemistry and The Skaggs Institute for Chemical Biology and William E. Balch is at the Department of Cell Biology and The Institute for Childhood and Neglected Disease, The Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, California 92130, USA. e-mail: jkelly@scripps.edu or e-mail: webalch@scripps.edu
Abstract
Eukaryotic cells are specialized, interdependent functional units of complex tissues that are composed of metabolically integrated systems defined by chemically distinct organelles that operate as reaction vessels. It is now clear that the small-molecule and polymer-based composition of these organelles plays a crucial role in generating and maintaining protein folds and functions through the systems chemistry of the local environments.
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