Supplementary information
From the following article
Functional characterization of IRESes by an inhibitor of the RNA helicase eIF4A
Marie-Eve Bordeleau, Ayaka Mori, Monika Oberer, Lisa Lindqvist, Louisa S Chard, Tatsuo Higa, Graham J Belsham, Gerhard Wagner, Junichi Tanaka & Jerry Pelletier
Nature Chemical Biology 2, 213 - 220 (2006) Published online: 12 March 2006
doi:10.1038/nchembio776
Supplementary Fig. 1
Hippuristanol inhibits translation in rabbit reticulocyte lysates and wheat germ extracts.
Supplementary Fig. 2
Effect of hippuristanol on protein, RNA and DNA synthesis in vivo.
Supplementary Fig. 3
Hippuristanol does not inhibit crosslinking of eIF4B to RNA.
Supplementary Fig. 4
Hippuristanol can distinguish between eIF4A–dependent and eIF4A–independent translation in vitro.
Supplementary Fig. 5
Determination of the IC50 for hippuristanol on HeLa cell proliferation.
Supplementary Fig. 6
Structure–activity relationship of hippuristanol congeners.
Supplementary Fig. 7
Effect of hippuristanol congeners on eIF4AIf mediated helicase activity.
Supplementary Methods
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