In This Issue - pv
doi:10.1038/nchembio0406-v
Table of contents
April 2006, Volume 2 No 4 pp169-221
- In This Issue
- Editorial
- Commentary
- News and Views
- Review
- Brief Communication
- Letters
- Article
- Corrigendum
- Erratum
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Editorial
Biology and brimstone - p169
doi:10.1038/nchembio0406-169
Full Text - Biology and brimstone | PDF (125 KB) - Biology and brimstone
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Commentary
Iron-sulfur clusters: ever-expanding roles - pp171 - 174
Marc Fontecave
doi:10.1038/nchembio0406-171
Iron-sulfur clusters have critical roles in proteins from diverse organisms and in a broad range of biological processes. Recent discoveries raise exciting challenges for future research by bioinorganic chemists and chemical biologists.
Full Text - Iron-sulfur clusters: ever-expanding roles | PDF (179 KB) - Iron-sulfur clusters: ever-expanding roles
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News and Views
Untangling the estrogen receptor web - pp175 - 176
Ross V Weatherman
doi:10.1038/nchembio0406-175
GPR30, a G-protein coupled receptor, is a recent addition to the family of receptors that bind to estrogens and antiestrogens. A new, selective compound for GPR30 has been developed to dissect the role of GPR30 in estrogen signaling.
Full Text - Untangling the estrogen receptor web | PDF (393 KB) - Untangling the estrogen receptor web
See also: Letter by Bologa et al.
Small molecule derails translation initiation - pp176 - 177
Tatyana V Pestova & Christopher U T Hellen
doi:10.1038/nchembio0406-176
Eukaryotic initiation factor (eIF) 4A plays an essential role in translation initiation on most eukaryotic mRNAs by unwinding their secondary structure to permit ribosomal attachment and scanning. The natural product hippuristanol selectively inhibited eIF4A- and eIF4A-dependent modes of translation initiation.
Full Text - Small molecule derails translation initiation | PDF (129 KB) - Small molecule derails translation initiation
See also: Article by Bordeleau et al.
Gold-plating MHC class II molecules - pp178 - 179
Paul A Roche
doi:10.1038/nchembio0406-178
Square-planar, four-coordinate metal complexes strip peptides from the binding site of MHC class II molecules. Removal of peptides derived from self-antigens could prevent class II–dependent activation of self-reactive T cells in autoimmune diseases such as rheumatoid arthritis.
Full Text - Gold-plating MHC class II molecules | PDF (117 KB) - Gold-plating MHC class II molecules
See also: Letter by De Wall et al.
How to evolve a silk purse from a sow's ear - pp179 - 180
David E Cane
doi:10.1038/nchembio0406-179
The enzyme 
-humulene synthase normally generates a mixture of more than 50 sesquiterpene products from a single substrate. Targeted evolution allowed the design of new mutants with greatly enhanced product specificity. The results provide a model for the divergent evolution of enzyme specificity from ancestral proteins of promiscuous function.
Full Text - How to evolve a silk purse from a sow's ear | PDF (119 KB) - How to evolve a silk purse from a sow's ear
Imaging gene expression: tiny signals make a big noise - pp181 - 182
Diane Longo & Jeff Hasty
doi:10.1038/nchembio0406-181
The hypothesis of ubiquitous fluctuations in gene expression has spurred the development of general methods for tracking temporal changes in protein concentrations in individual cells. The determination of protein levels with single-molecule sensitivity represents a significant advancement in the monitoring of cellular behavior that is driven by gene expression.
Full Text - Imaging gene expression: tiny signals make a big noise | PDF (307 KB) - Imaging gene expression: tiny signals make a big noise
Orchestrating sulfur incorporation into RNA - pp182 - 183
Charles T Lauhon
doi:10.1038/nchembio0406-182
The modified tRNA base 2-thiouridine is required for many steps in translation. Surprisingly, the biosynthesis of this simple derivative requires a minimum of four sulfur transfer reactions involving seven proteins.
Full Text - Orchestrating sulfur incorporation into RNA | PDF (111 KB) - Orchestrating sulfur incorporation into RNA
Research Highlights - p184
doi:10.1038/nchembio0406-184
Full Text - Research Highlights | PDF (141 KB) - Research Highlights
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Review
Trafficking in persulfides: delivering sulfur in biosynthetic pathways - pp185 - 194
Eugene G Mueller
doi:10.1038/nchembio779
Abstract - Trafficking in persulfides: delivering sulfur in biosynthetic pathways | Full Text - Trafficking in persulfides: delivering sulfur in biosynthetic pathways | PDF (350 KB) - Trafficking in persulfides: delivering sulfur in biosynthetic pathways
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Brief Communication
Heparan sulfate C5-epimerase is essential for heparin biosynthesis in mast cells - pp195 - 196
Thorsten B Feyerabend, Jin-Ping Li, Ulf Lindahl & Hans-Reimer Rodewald
doi:10.1038/nchembio777
Abstract - Heparan sulfate C5-epimerase is essential for heparin biosynthesis in mast cells | Full Text - Heparan sulfate C5-epimerase is essential for heparin biosynthesis in mast cells | PDF (175 KB) - Heparan sulfate C5-epimerase is essential for heparin biosynthesis in mast cells | Supplementary information
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Letters
Noble metals strip peptides from class II MHC proteins - pp197 - 201
Stephen L De Wall, Corrie Painter, Jennifer D Stone, Rajintha Bandaranayake, Don C Wiley, Timothy J Mitchison, Lawrence J Stern & Brian S DeDecker
doi:10.1038/nchembio773
First Paragraph - Noble metals strip peptides from class II MHC proteins | Full Text - Noble metals strip peptides from class II MHC proteins | PDF (241 KB) - Noble metals strip peptides from class II MHC proteins | Supplementary information | Chemical compounds
See also: News and Views by Roche
An shRNA barcode screen provides insight into cancer cell vulnerability to MDM2 inhibitors - pp202 - 206
Thijn R Brummelkamp, Armida W M Fabius, Jasper Mullenders, Mandy Madiredjo, Arno Velds, Ron M Kerkhoven, René Bernards & Roderick L Beijersbergen
doi:10.1038/nchembio774
First Paragraph - An shRNA barcode screen provides insight into cancer cell vulnerability to MDM2 inhibitors | Full Text - An shRNA barcode screen provides insight into cancer cell vulnerability to MDM2 inhibitors | PDF (424 KB) - An shRNA barcode screen provides insight into cancer cell vulnerability to MDM2 inhibitors | Chemical compounds
Virtual and biomolecular screening converge on a selective agonist for GPR30 - pp207 - 212
Cristian G Bologa, Chetana M Revankar, Susan M Young, Bruce S Edwards, Jeffrey B Arterburn, Alexander S Kiselyov, Matthew A Parker, Sergey E Tkachenko, Nikolay P Savchuck, Larry A Sklar, Tudor I Oprea & Eric R Prossnitz
doi:10.1038/nchembio775
First Paragraph - Virtual and biomolecular screening converge on a selective agonist for GPR30 | Full Text - Virtual and biomolecular screening converge on a selective agonist for GPR30 | PDF (454 KB) - Virtual and biomolecular screening converge on a selective agonist for GPR30 | Supplementary information | Chemical compounds
See also: News and Views by Weatherman
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Article
Functional characterization of IRESes by an inhibitor of the RNA helicase eIF4A - pp213 - 220
Marie-Eve Bordeleau, Ayaka Mori, Monika Oberer, Lisa Lindqvist, Louisa S Chard, Tatsuo Higa, Graham J Belsham, Gerhard Wagner, Junichi Tanaka & Jerry Pelletier
doi:10.1038/nchembio776
Abstract - Functional characterization of IRESes by an inhibitor of the RNA helicase eIF4A | Full Text - Functional characterization of IRESes by an inhibitor of the RNA helicase eIF4A | PDF (660 KB) - Functional characterization of IRESes by an inhibitor of the RNA helicase eIF4A | Supplementary information | Chemical compounds
See also: News and Views by Pestova & Hellen
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Corrigendum
Corrigendum: Rethinking 'secondary' metabolism: physiological roles for phenazine antibiotics - p221
Alexa Price-Whelan, Lars E P Dietrich & Dianne K Newman
doi:10.1038/nchembio0406-221a
Full Text - Corrigendum: Rethinking 'secondary' metabolism: physiological roles for phenazine antibiotics | PDF (122 KB) - Corrigendum: Rethinking 'secondary' metabolism: physiological roles for phenazine antibiotics
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Top of pageErratum
Erratum: Secramine inhibits Cdc42-dependent functions in cells and Cdc42 activation in vitro - p221
Henry E Pelish, Jeffrey R Peterson, Susana B Salvarezza, Enrique Rodriguez-Boulan, Ji-Long Chen, Mark Stamnes, Eric Macia, Yan Feng, Matthew D Shair & Tomas Kirchhausen
doi:10.1038/nchembio0406-221b
Full Text - Erratum: Secramine inhibits Cdc42-dependent functions in cells and Cdc42 activation in vitro | PDF (122 KB) - Erratum: Secramine inhibits Cdc42-dependent functions in cells and Cdc42 activation in vitro
