News and Views
Nature Chemical Biology 2, 181 - 182 (2006)
doi:10.1038/nchembio0406-181
Imaging gene expression: tiny signals make a big noise
- Diane Longo is in the Department of Bioengineering and Jeff Hasty is in the Department of Bioengineering and the Institute for Nonlinear Science, University of California San Diego, La Jolla, California 92093, USA. e-mail: hasty@ucsd.edu
Abstract
The hypothesis of ubiquitous fluctuations in gene expression has spurred the development of general methods for tracking temporal changes in protein concentrations in individual cells. The determination of protein levels with single-molecule sensitivity represents a significant advancement in the monitoring of cellular behavior that is driven by gene expression.
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