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Nature Chemical Biology 2, 178 - 179 (2006)
doi:10.1038/nchembio0406-178
Gold-plating MHC class II molecules
Paul A Roche1
- Paul A. Roche is in the Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, 9000 Rockville Pike, Bethesda, Maryland 20892, USA. e-mail: paul.roche@nih.gov
Abstract
Square-planar, four-coordinate metal complexes strip peptides from the binding site of MHC class II molecules. Removal of peptides derived from self-antigens could prevent class II–dependent activation of self-reactive T cells in autoimmune diseases such as rheumatoid arthritis.
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RESEARCH
Noble metals strip peptides from class II MHC proteinsNature Chemical Biology Letter (01 Apr 2006)
