1. Tatyana V. Pestova and Christopher U.T. Hellen are in the Department of Microbiology and Immunology, the State University of New York Downstate Medical Center, 450 Clarkson Avenue, Brooklyn, New York 11203, USA. e-mail: tatyana.pestova@downstate.edu

Abstract

Eukaryotic initiation factor (eIF) 4A plays an essential role in translation initiation on most eukaryotic mRNAs by unwinding their secondary structure to permit ribosomal attachment and scanning. The natural product hippuristanol selectively inhibited eIF4A- and eIF4A-dependent modes of translation initiation.

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