1. Mark Howarth and Alice Y. Ting are in the Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA. e-mail: ating@mit.edu

Abstract

Looked at from the outside of the cell, proteins are often hidden behind a forest of sugar chains. Using a sugar analog to introduce thiols onto the tips of the branches of this forest alters cell attachment and has unexpected consequences for cell differentiation.

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