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Nature Chemical Biology 2, 69 (1 February 2006) | doi:10.1038/nchembio0206-69
Research Highlights
Abstract
Un-sirtuin effects of natural products The sirtuins are a family of NAD+-dependent deacetylases with a range of substrates including p53, FOXO and histones. Mutational studies of the yeast sirtuin Sir2p and of two members of the human sirtuin family, SIRT1 and SIRT2, has implicated this family in determining life span, telomere maintenance and transcription of key apoptotic regulators.
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