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Letter
Nature Chemical Biology 2, 720–723 (1 December 2006) | doi:10.1038/nchembio831
Deconstructing fragment-based inhibitor discovery
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Abstract
Fragment-based screens test multiple low–molecular weight molecules for binding to a target. Fragments often bind with low affinities but typically have better ligand efficiencies (|[Delta]|Gbind/heavy atom count) than traditional screening hits.
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