1. Jörn Piel is in the Kekulé Institute of Organic Chemistry and Biochemistry, University of Bonn, Gerhard-Domagk-Str. 1, 53121 Bonn, Germany. e-mail: joern.piel@uni-bonn.de

Abstract

Ascidians obtain diverse libraries of cytotoxic compounds by maintaining cyanobacterial symbionts that have combinatorial variants of a natural-product pathway. The biosynthetic flexibility of this route can be used to genetically engineer new substances.

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