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From the following article

Structural basis for macrolactonization by the pikromycin thioesterase

David L Akey, Jeffrey D Kittendorf, John W Giraldes, Robert A Fecik, David H Sherman & Janet L Smith

Nature Chemical Biology 2, 537 - 542 (2006) Published online: 10 September 2006

doi:10.1038/nchembio824

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Figure 1 - Unfortunately we are unable to provide accessible alternative text for this. If you require assistance to access this image, or to obtain a text description, please contact npg@nature.com

Figure 1

Affinity label adduct and macrolactone product within the Pik TE active site.

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Figure 2

Electrostatic surface representation of Pik TE substrate channel with affinity label and with macrolactone product.

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Figure 3

Model of acyl-serine hepta- and hexaketides in the active site shown from the top views (left; orientation is similar to that in Fig. 1b) and side views (right).

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Scheme 1 - Unfortunately we are unable to provide accessible alternative text for this. If you require assistance to access this image, or to obtain a text description, please contact npg@nature.com

Scheme 1

Pikromycin biosynthesis and substrate mimics.

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