Figure 1 - Affinity label adduct and macrolactone product within the Pik TE active site.

From the following article

Structural basis for macrolactonization by the pikromycin thioesterase

David L Akey, Jeffrey D Kittendorf, John W Giraldes, Robert A Fecik, David H Sherman & Janet L Smith

Nature Chemical Biology 2, 537 - 542 (2006) Published online: 10 September 2006

doi:10.1038/nchembio824

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Red, O; orange, P; blue, N; green, S; red spheres, water. (a) Refined 2Fo – Fc electron density contoured at 1 sigma around the modified serine-phosphopentaketide. (b) Stereodiagram of modified serine-phosphopentaketide detailing protein-substrate interactions. Phosphopentaketide 11 main chain atoms are numbered beginning with the proximal phosphorus atom (P1). (c) Refined 2Fo – Fc electron density contoured at 1 sigma around the 10-deoxymethynolide and DMSO molecules trapped within the active site of Pik TE. (d) Stereodiagram of 10-deoxymethynolide (10-DML) detailing product and DMSO interactions.

Figures, schemes and tables index
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