Supplementary information : Secramine inhibits Cdc42-dependent functions in cells and Cdc42 activation : in vitro : Nature Chemical Biology

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Secramine inhibits Cdc42-dependent functions in cells and Cdc42 activation in vitro

Henry E Pelish, Jeffrey R Peterson, Susana B Salvarezza, Enrique Rodriguez-Boulan, Ji-Long Chen, Mark Stamnes, Eric Macia, Yan Feng, Matthew D Shair & Tomas Kirchhausen

Nature Chemical Biology 2, 39 - 46 (2006) Published online: 20 November 2005 Corrected online: 1 July 0603

doi:10.1038/nchembio751

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Supplementary Fig. 1

Screening results for galanthamine-like library.

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Supplementary Fig. 2

Effects of secramine on the secretory pathway.

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Supplementary Fig. 3

Inhibition of Rac1 activation by secramine.

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Supplementary Video 1

BS-C-1 cells expressing VSVG^ts-EGFP at 40°C were treated with cycloheximide and 1% DMSO (vehicle) for 10 min followed by transfer to 32°C and image acquisition.

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Supplementary Video 2

BS-C-1 cells expressing VSVG^ts-EGFP at 40°C were treated with cycloheximide and 10 M secramine A for 10 min followed by transfer to 32°C and image acquisition.