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Nature Chemical Biology 2, 10–11 (1 January 2006) | doi:10.1038/nchembio0106-10

Agonizing Hedgehog

James Briscoe

The Hedgehog (Hh) family of secreted proteins are intercellular signals that control cell proliferation and differentiation. They are responsible for embryonic processes that range from limb formation and neuronal specification to bone differentiation.