1. James Briscoe is in the Department of Developmental Neurobiology, National Institute for Medical Research, London, NW7 1AA, UK. e-mail: james.briscoe@nimr.mrc.ac.uk

Abstract

Hedgehog signaling has important and pleiotropic roles in embryonic and adult tissues. A small-molecule agonist of this pathway has been shown to act by targeting the transmembrane protein Smoothened.

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