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Synthetic biology

Reframing cell therapy for cancer

Nature Chemical Biology volume 14, pages 204–205 (2018)Cite this article

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Technologies for engineering immune cells to recognize features on cancer cells are transforming oncology. Synthetic biologists now expand this approach by conferring therapeutic functions to nonimmune cells and by programming cells to sense and respond to a new class of physiological cues.

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Figure 1: Comparison across frameworks for engineering cells to respond to cancer.

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Authors and Affiliations

  1. Department of Chemical and Biological Engineering and the Center for Synthetic Biology, Northwestern University, Evanston, Illinois, USA

    Taylor B Dolberg, Patrick S Donahue & Joshua N Leonard

  2. Interdisciplinary Biological Sciences Program, Northwestern University, Evanston, Illinois, USA

    Patrick S Donahue

  3. Medical Scientist Training Program, Northwestern University, Chicago, Illinois, USA

    Patrick S Donahue

Authors
  1. Taylor B Dolberg
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  2. Patrick S Donahue
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  3. Joshua N Leonard
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Corresponding author

Correspondence to Joshua N Leonard.

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The authors declare no competing financial interests.

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Dolberg, T., Donahue, P. & Leonard, J. Reframing cell therapy for cancer. Nat Chem Biol 14, 204–205 (2018). https://doi.org/10.1038/nchembio.2573

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