G-protein-coupled receptors (GPCRs) are critically involved in signal transduction. Structural views of several GPCRs have recently been obtained, but the structural principles determining subtype selectivity are still mostly elusive. Now, a combined solid-state NMR and molecular-modeling approach reveals how bradykinin GPCRs distinguish between closely related peptide ligands.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Hauser, A.S., Attwood, M.M., Rask-Andersen, M., Schiöth, H.B. & Gloriam, D.E. Nat. Rev. Drug. Disc. 16, 829–842 (2017).
Joedicke, L. et al. Nat. Chem. Biol. 14, 284–290 (2018).
Luca, S. et al. Proc. Natl. Acad. Sci. USA 100, 10706–10711 (2003).
Heise, H., Luca, S., de Groot, B.L., Grubmüller, H. & Baldus, M. Biophys. J. 89, 2113–2120 (2005).
Lopez, J.J. et al. Angew. Chem. Int. Ed. Engl. 47, 1668–1671 (2008).
Park, S.H. et al. Nature 491, 779–783 (2012).
Ni, Q.Z. et al. Acc. Chem. Res. 46, 1933–1941 (2013).
Nygaard, R. et al. Cell 152, 532–542 (2013).
Kaplan, M. et al. Cell 167, 1241–1251.e11 (2016).
Glukhova, A. et al. Cell 168, 867–877.e13 (2017).
Rosholm, K.R. et al. Nat. Chem. Biol. 13, 724–729 (2017).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The author declares no competing financial interests.
Rights and permissions
About this article
Cite this article
Baldus, M. Lock and key become flexible. Nat Chem Biol 14, 201–202 (2018). https://doi.org/10.1038/nchembio.2567
Published:
Issue Date:
DOI: https://doi.org/10.1038/nchembio.2567