Extracellular vesicles (EVs) are a class of secreted membrane particles capable of transferring biological molecules between cells. Metabolomics measurements indicate that isolated EVs also have autonomous metabolic enzyme activities, including the unexpected identification of endogenous human asparaginase activity.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Raposo, G. & Stoorvogel, W. J. Cell Biol. 200, 373–383 (2013).
Iraci, N. et al. Nat. Chem. Biol. 13, 951–955 (2017).
Zhao, H. et al. eLife 5, e10250 (2016).
Valadi, H. et al. Nat. Cell Biol. 9, 654–659 (2007).
Garcia, N.A., Moncayo-Arlandi, J., Sepulveda, P. & Diez-Juan, A. Cardiovasc. Res. 109, 397–408 (2016).
Ronquist, K.G., Ek, B., Stavreus-Evers, A., Larsson, A. & Ronquist, G. Am. J. Physiol. Endocrinol. Metab. 304, E576–E582 (2013).
Schalk, A.M., Nguyen, H.A., Rigouin, C. & Lavie, A. J. Biol. Chem. 289, 33175–33186 (2014).
Cantor, J.R., Stone, E.M., Chantranupong, L. & Georgiou, G. Biochemistry 48, 11026–11031 (2009).
Pui, C.H. & Evans, W.E. N. Engl. J. Med. 354, 166–178 (2006).
Vander Heiden, M.G. & DeBerardinis, R.J. Cell 168, 657–669 (2017).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The author declares no competing financial interests.
Rights and permissions
About this article
Cite this article
Sullivan, L. Taking metabolism on the road. Nat Chem Biol 13, 924–925 (2017). https://doi.org/10.1038/nchembio.2455
Published:
Issue Date:
DOI: https://doi.org/10.1038/nchembio.2455
This article is cited by
-
Nucleic acid and nanomaterial-assisted signal-amplified strategies in fluorescent analysis of circulating tumor cells and small extracellular vesicles
Analytical and Bioanalytical Chemistry (2023)