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Locking down metabolism

Nature Chemical Biology volume 13, pages 925–926 (2017)Cite this article

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An allosteric inhibitor of Mycobacterium tuberculosis tryptophan synthase—an enzyme that is nonessential for in vitro growth—has potent antimicrobial activity, revealing a potentially expanded target list for antimicrobials and greater chemical space for new inhibitors.

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Figure 1: Intermediary metabolism and allosteric inhibitors increase target space for new antimicrobials.

Katie Vicari/Springer Nature

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Authors and Affiliations

  1. Center for Tuberculosis Research, Johns Hopkins School of Medicine, Baltimore, Maryland, USA

    William R Bishai

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  1. William R Bishai
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Correspondence to William R Bishai.

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Bishai, W. Locking down metabolism. Nat Chem Biol 13, 925–926 (2017). https://doi.org/10.1038/nchembio.2452

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