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Structural biology

Full monty of family B GPCRs

Nature Chemical Biology volume 13, pages 819–821 (2017)Cite this article

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New structures of the glucagon-like peptide-1 (GLP-1) and glucagon receptors in complex with peptide and nonpeptide ligands provide a comprehensive, detailed picture of the molecular mechanisms of action of family B GPCRs. This opens the door for true structure-based drug discovery aimed at both novel orthosteric and allosteric subsites of the receptors.

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Figure 1: Ligand binding and activation of a family B GPCR and the GLP-1 receptor.

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Authors and Affiliations

  1. Department of Biomedical Research at University of Copenhagen, Section for Metabolic Receptology at the Center for Basic Metabolic Research and Laboratory for Molecular Pharmacology,

    Thue W Schwartz

  2. Section for Metabolic Receptology at the Center for Basic Metabolic Research at University of Copenhagen,

    Thomas M Frimurer

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  1. Thue W Schwartz
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  2. Thomas M Frimurer
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Correspondence to Thue W Schwartz or Thomas M Frimurer.

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Schwartz, T., Frimurer, T. Full monty of family B GPCRs. Nat Chem Biol 13, 819–821 (2017). https://doi.org/10.1038/nchembio.2438

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