Enzymology and structural and functional characterization of some FAD-dependent monooxygenases provide insights into degradation of tetracycline antibiotics, but also show unexpected features of substrate recognition, reaction mechanism, and competitive inhibition.
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Petkovic, S., Hinrichs, W. Blocking tetracycline destruction. Nat Chem Biol 13, 694–695 (2017). https://doi.org/10.1038/nchembio.2396
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DOI: https://doi.org/10.1038/nchembio.2396
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