To fully leverage the potential of human-induced pluripotent stem cells (hiPSCs), improved and standardized reprogramming methods and large-scale collections of hiPSC lines are needed, and the stem cell community must embrace chemical biology methodology for target identification and validation.
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Ursu, A., Schöler, H. & Waldmann, H. Small-molecule phenotypic screening with stem cells. Nat Chem Biol 13, 560–563 (2017). https://doi.org/10.1038/nchembio.2383
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DOI: https://doi.org/10.1038/nchembio.2383