Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Optogenetics

Switching with red and blue

Multiple optogenetic technologies are required to control biological activity simultaneously with different colors of light. Optimizing a near-infrared-induced heterodimerization system, which can be combined with blue-light-controlled domains, enables precise spatiotemporal control of target molecules in live mammalian cells.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Comparison of the light-dependent properties of existing red-light-based optogenetic systems using different phytochromes.

References

  1. Nagel, G. et al. Proc. Natl. Acad. Sci. USA 100, 13940–13945 (2003).

    Article  CAS  Google Scholar 

  2. Kennedy, M.J. et al. Nat. Methods 7, 973–975 (2010).

    Article  CAS  Google Scholar 

  3. Wu, Y.I. et al. Nature 461, 104–108 (2009).

    Article  CAS  Google Scholar 

  4. Gautier, A. et al. Nat. Chem. Biol. 10, 533–541 (2014).

    Article  CAS  Google Scholar 

  5. Redchuk, T.A., Omelina, E.S., Chernov, K.G. & Verkhusha, V.V. Nat. Chem. Biol. 13, 633–639 (2017).

    Article  CAS  Google Scholar 

  6. Reichhart, E., Ingles-Prieto, A., Tichy, A.M., McKenzie, C. & Janovjak, H. Angew. Chem. Int. Ed. Engl. 55, 6339–6342 (2016).

    Article  CAS  Google Scholar 

  7. Shimizu-Sato, S., Huq, E., Tepperman, J.M. & Quail, P.H. Nat. Biotechnol. 20, 1041–1044 (2002).

    Article  CAS  Google Scholar 

  8. Levskaya, A., Weiner, O.D., Lim, W.A. & Voigt, C.A. Nature 461, 997–1001 (2009).

    Article  CAS  Google Scholar 

  9. Müller, K. et al. Chem. Commun. (Camb.) 49, 8970–8972 (2013).

    Article  Google Scholar 

  10. Kaberniuk, A.A., Shemetov, A.A. & Verkhusha, V.V. Nat. Methods 13, 591–597 (2016).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Masayuki Yazawa.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Kawano, F., Shi, F. & Yazawa, M. Switching with red and blue. Nat Chem Biol 13, 573–574 (2017). https://doi.org/10.1038/nchembio.2387

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nchembio.2387

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing