Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Protein folding

Illuminating chaperone activity

Nature Chemical Biology volume 13, pages 346–347 (2017)Cite this article

Subjects

Pharmacological chaperones are small drugs that stabilize a protein's fold and are being developed to treat diseases arising from protein misfolding. A mathematical framework to model their activity in cells enables insight into their mechanism and capacity to rescue protein foldedness.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Influence of pharmacological chaperones on protein-folding landscape.

References

  1. Kim, Y.E., Hipp, M.S., Bracher, A., Hayer-Hartl, M. & Hartl, F.U. Annu. Rev. Biochem. 82, 323–355 (2013).

    Article  CAS  Google Scholar 

  2. Bernier, V., Lagacé, M., Bichet, D.G. & Bouvier, M. Trends Endocrinol. Metab. 15, 222–228 (2004).

    Article  CAS  Google Scholar 

  3. Quon, B.S. & Rowe, S.M. Br. Med. J. 352, i859 (2016).

    Article  Google Scholar 

  4. Hingorani, K.S. et al. Nat. Chem. Biol. 13, 369–371 (2017).

    Article  CAS  Google Scholar 

  5. Braselmann, E. & Clark, P.L. J. Phys. Chem. Lett. 3, 1063–1071 (2012).

    Article  CAS  Google Scholar 

  6. Fedorov, A.N. & Baldwin, T.O. J. Biol. Chem. 272, 32715–32718 (1997).

    Article  CAS  Google Scholar 

  7. Baneyx, F. & Mujacic, M. Nat. Biotechnol. 22, 1399–1408 (2004).

    Article  CAS  Google Scholar 

  8. Glasscock, C.J., Lucks, J.B. & DeLisa, M.P. Cell. Chem. Biol. 23, 45–56 (2016).

    Article  CAS  Google Scholar 

  9. Mahalik, S., Sharma, A.K. & Mukherjee, K.J. Microb. Cell Fact. 13, 177 (2014).

    Article  Google Scholar 

  10. Young, C.L. & Robinson, A.S. Curr. Opin. Biotechnol. 30, 168–177 (2014).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Danny M. Hatters is in the Department of Biochemistry and Molecular Biology, The University of Melbourne, Melbourne, Australia.,

    Danny M Hatters

Authors
  1. Danny M Hatters
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Danny M Hatters.

Ethics declarations

Competing interests

The author declares no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Hatters, D. Illuminating chaperone activity. Nat Chem Biol 13, 346–347 (2017). https://doi.org/10.1038/nchembio.2332

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nchembio.2332

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing