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February 2017 Volume 13 No 2

Peptides based on sequences of glycine receptors that interact with gephyrin have been developed that have enhanced affinity and specificity toward blocking gephyrin interactions with these postsynaptic inhibitory receptors. These super-binding peptides are useful for isolating and localizing native gephyrin and for modulating glycinergic synaptic transmission (depicted as stars in a synaptic space of a glass-like neurotransmitter-releasing neuron and a postsynaptic target cell). Cover design by Erin Dewalt, based on an image created by Henning Dalhoff. Article, p153

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