About the cover

August 2016 Volume 12 No 8

The Hsp90 chaperone resembles a molecular clamp that opens and closes in response to ATP binding and hydrolysis. The cover features the use of high-resolution fluorescence probes consisting of a dye molecule (orange/red) and the amino acid tryptophan (blue/green) to detect changes in Hsp90 conformational motion through photo-induced electron transfer (PET)-mediated quenching of fluorescence by tryptophan residues in the protein. The background depicts the dynamic Hsp90 conformations observed by PET fluorescence, showing proteins in the open (gold molecules) and closed (blue molecules) conformations. Cover design by Erin Dewalt, based on an image created by Laurence Pearl. Article, p628; News and Views, p576