Natural (βα)8-barrel proteins support diverse catalytic functions and are fertile scaffolds for engineering synthetic enzymes. The atomic-resolution structure determination of a computationally guided, de novo–designed symmetric barrel is a long-awaited advance that opens up new opportunities for enzyme design.
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Nanda, V. Getting to the bottom of the TIM barrel. Nat Chem Biol 12, 2–3 (2016). https://doi.org/10.1038/nchembio.1987
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DOI: https://doi.org/10.1038/nchembio.1987