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Pharmacodynamics

Which trails are your drugs taking?

Binding kinetics (BK) has an indispensable role in pharmacodynamics (PD). Incorporating slow BK into a mechanistic PD model is shown to have predictive value for in vitro cellular and in vivo animal antibacterial efficacy.

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Figure 1: Crafting right-trailed drugs on BK-undergirded Mount PKPD.

Marina Corral Spence/Nature Publishing Group

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Correspondence to Rumin Zhang.

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Zhang, R. Which trails are your drugs taking?. Nat Chem Biol 11, 382–383 (2015). https://doi.org/10.1038/nchembio.1795

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