Binding kinetics (BK) has an indispensable role in pharmacodynamics (PD). Incorporating slow BK into a mechanistic PD model is shown to have predictive value for in vitro cellular and in vivo animal antibacterial efficacy.
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Zhang, R. Which trails are your drugs taking?. Nat Chem Biol 11, 382–383 (2015). https://doi.org/10.1038/nchembio.1795
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DOI: https://doi.org/10.1038/nchembio.1795
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