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Small-molecule inhibitors

Viral fusion arrested

Nature Chemical Biology volume 10, pages 797–798 (2014)Cite this article

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A newly discovered small molecule with broad reactivity against diverse HIV-1 strains prevents the surface envelope glycoprotein from fusing with host cells and offers a potential new anti–HIV-1 target.

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Figure 1: The fusion machinery for HIV-1 is triggered by binding to the host CD4 receptor (blue ovals) and the CCR5–CXCR4 co-receptor (brown box).

Debbie Maizels/Nature Publishing Group

References

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Authors and Affiliations

  1. Andrew B. Ward is in the Scripps Research Institute, California, La Jolla, California, USA.,

    Andrew B Ward

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  1. Andrew B Ward
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Correspondence to Andrew B Ward.

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The author declares no competing financial interests.

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Ward, A. Viral fusion arrested. Nat Chem Biol 10, 797–798 (2014). https://doi.org/10.1038/nchembio.1632

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