Supplementary information
From the following article
Monocarboxylate transporter MCT1 is a target for immunosuppression
Clare M Murray, Raymond Hutchinson, John R Bantick, Graham P Belfield, Amanda D Benjamin, Diana Brazma, Robert V Bundick, I David Cook, Robert I Craggs, Susan Edwards, Leslie R Evans, Richard Harrison, Elain Holness, Andrew P Jackson, Clive G Jackson, Lee P Kingston, Matthew W D Perry, Andrew R J Ross, Paul A Rugman, Sasvinder S Sidhu, Michael Sullivan, David A Taylor-Fishwick, P Craig Walker, Yvonne M Whitehead, David J Wilkinson, Andrew Wright & David K Donald
Nature Chemical Biology 1, 371 - 376 (2005) Published online: 30 October 2005
doi:10.1038/nchembio744
Supplementary Fig. 1
Effects of novel immunomodulators on in vitro human T-lymphocyte responses.
Supplementary Fig. 2
Effect of MCT1 inhibitors on the intracellular pH of human T-lymphocytes.
Supplementary Table 1
Chemical structures and names.
Supplementary Table 2
Effect of compound 1 on proliferation of human cells.
Supplementary Table 3
Correlation between compound binding to Jurkat T-cells and MCT1 and inhibition of PBMC proliferation.
Supplementary Table 4
Correlation between compound effects on lactate levels, DNA synthesis and inhibition of proliferation in human T-cells.
Supplementary Methods
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