Abstract
Various strategies have been developed recently for imparting light sensitivity onto normally insensitive cells. These include expression of natural photosensitive proteins, photolysis of caged agonists of native cell surface receptors and photoswitching of isomerizable tethered ligands that act on specially engineered ion channels and receptor targets. The development of chemical tools for optically stimulating or inhibiting signaling proteins has particular relevance for the nervous system, where precise, noninvasive control is an experimental and medical necessity.
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Acknowledgements
This work was supported by a Laboratory Directed Research and Development (LDRD) grant from Lawrence Berkeley National Laboratory (R.K and D.T.) and grants from the National Institutes of Health (R.K.).
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Kramer, R., Chambers, J. & Trauner, D. Photochemical tools for remote control of ion channels in excitable cells. Nat Chem Biol 1, 360–365 (2005). https://doi.org/10.1038/nchembio750
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DOI: https://doi.org/10.1038/nchembio750
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