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Letter
Nature Chemical Biology 1, 383–388 (1 December 2005) | doi:10.1038/nchembio748
Actin is the primary cellular receptor of bistramide A
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Abstract
Bistramide A (1) is a marine natural product with broad, potent antiproliferative effects. Bistramide A has been reported to selectively activate protein kinase C (PKC) |[delta]|, leading to the view that PKC|[delta]| is the principal mediator of antiproliferative activity of this natural product.
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