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Volume 1 Issue 7, December 2005

Small-molecule suppression of zebrafish mutants. Using a chemical genetic screen, Stern et al. (p 366) identified persynthamide, a compound that suppresses the crash&burn (crb) mutation in zebrafish by inhibiting S phase of the cell cycle (see also News & Views by Sidi & Look, p 351). The image shows zebrafish embryos immunostained with an antibody specific for phosphorylation of Ser10 of histone H3, a marker of mitotic cells. Cover art by Erin Boyle, based on images provided by Christian Straub.

Volume 1 Issue 7

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Editorial

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News & Views

  • The zebrafish has become a popular model organism to investigate many biological processes, in part owing to the combination of facile genetic manipulation and rapid, external embryonic development. The application of large-scale screening to identify chemical suppressors of a cancer-prone mutant highlights new technology for whole organism–based small-molecule discovery.

    • Samuel Sidi
    • A Thomas Look
    News & Views

  • Development of small-molecule agonists against members of the tumor necrosis factor (TNF) receptor superfamily remains a considerable challenge. Presentation of ligand-derived peptides on a trimeric scaffold may point the way toward development of potent small-molecule agonists against this biologically important protein superfamily.

    • Sarah G Hymowitz
    • Avi Ashkenazi
    News & Views

  • Sir2 is a key regulator in promoting longevity in response to a low-calorie diet. A new role for nitric oxide in promoting mitochondrial synthesis may be the reason why.

    • Leonard Guarente
    News & Views

  • Identification of the monocarboxylate transporter 1 as a target of a new class of immunosuppressants shows that aerobic glycolysis and lactate release are essential for the proliferation of activated lymphocytes.

    • Stefan Bröer
    News & Views
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