In This Issue - pv
doi:10.1038/nchembio1205-v
Table of contents
December 2005, Volume 1 No 7 pp349-397
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News and Views
Small molecules thwart crash and burn - pp351 - 353
Samuel Sidi & A Thomas Look
doi:10.1038/nchembio1205-351
The zebrafish has become a popular model organism to investigate many biological processes, in part owing to the combination of facile genetic manipulation and rapid, external embryonic development. The application of large-scale screening to identify chemical suppressors of a cancer-prone mutant highlights new technology for whole organism–based small-molecule discovery.
Full Text - Small molecules thwart crash and burn | PDF (538 KB) - Small molecules thwart crash and burn
See also: Letter by Stern et al.
Toward small-molecule agonists of TNF receptors - pp353 - 354
Sarah G Hymowitz & Avi Ashkenazi
doi:10.1038/nchembio1205-353
Development of small-molecule agonists against members of the tumor necrosis factor (TNF) receptor superfamily remains a considerable challenge. Presentation of ligand-derived peptides on a trimeric scaffold may point the way toward development of potent small-molecule agonists against this biologically important protein superfamily.
Full Text - Toward small-molecule agonists of TNF receptors | PDF (180 KB) - Toward small-molecule agonists of TNF receptors
See also: Letter by Fournel et al.
NO link between calorie restriction and mitochondria - pp355 - 356
Leonard Guarente
doi:10.1038/nchembio1205-355
Sir2 is a key regulator in promoting longevity in response to a low-calorie diet. A new role for nitric oxide in promoting mitochondrial synthesis may be the reason why.
Full Text - NO link between calorie restriction and mitochondria | PDF (146 KB) - NO link between calorie restriction and mitochondria
Lactate transportation is required for lymphocyte activation - pp356 - 357
Stefan Bröer
doi:10.1038/nchembio1205-356
Identification of the monocarboxylate transporter 1 as a target of a new class of immunosuppressants shows that aerobic glycolysis and lactate release are essential for the proliferation of activated lymphocytes.
Full Text - Lactate transportation is required for lymphocyte activation | PDF (146 KB) - Lactate transportation is required for lymphocyte activation
See also: Letter by Murray et al.
Research Highlights - p359
doi:10.1038/nchembio1205-359
Full Text - Research Highlights | PDF (132 KB) - Research Highlights
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Perspective
Photochemical tools for remote control of ion channels in excitable cells - pp360 - 365
Richard H Kramer, James J Chambers & Dirk Trauner
doi:10.1038/nchembio750
Abstract - Photochemical tools for remote control of ion channels in excitable cells | Full Text - Photochemical tools for remote control of ion channels in excitable cells | PDF (410 KB) - Photochemical tools for remote control of ion channels in excitable cells
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Letters
Small molecules that delay S phase suppress a zebrafish bmyb mutant - pp366 - 370
Howard M Stern, Ryan D Murphey, Jennifer L Shepard, James F Amatruda, Christian T Straub, Kathleen L Pfaff, Gerhard Weber, John A Tallarico, Randall W King & Leonard I Zon
doi:10.1038/nchembio749
First Paragraph - Small molecules that delay S phase suppress a zebrafish : bmyb: mutant | Full Text - Small molecules that delay S phase suppress a zebrafish bmyb mutant | PDF (401 KB) - Small molecules that delay S phase suppress a zebrafish bmyb mutant | Supplementary information | Chemical compounds
See also: News and Views by Sidi & Look
Monocarboxylate transporter MCT1 is a target for immunosuppression - pp371 - 376
Clare M Murray, Raymond Hutchinson, John R Bantick, Graham P Belfield, Amanda D Benjamin, Diana Brazma, Robert V Bundick, I David Cook, Robert I Craggs, Susan Edwards, Leslie R Evans, Richard Harrison, Elain Holness, Andrew P Jackson, Clive G Jackson, Lee P Kingston, Matthew W D Perry, Andrew R J Ross, Paul A Rugman, Sasvinder S Sidhu, Michael Sullivan, David A Taylor-Fishwick, P Craig Walker, Yvonne M Whitehead, David J Wilkinson, Andrew Wright & David K Donald
doi:10.1038/nchembio744
First Paragraph - Monocarboxylate transporter MCT1 is a target for immunosuppression | Full Text - Monocarboxylate transporter MCT1 is a target for immunosuppression | PDF (315 KB) - Monocarboxylate transporter MCT1 is a target for immunosuppression | Supplementary information | Chemical compounds
See also: News and Views by Bröer
C3-symmetric peptide scaffolds are functional mimetics of trimeric CD40L - pp377 - 382
Sylvie Fournel, Sébastien Wieckowski, Weimin Sun, Nathalie Trouche, Hélène Dumortier, Alberto Bianco, Olivier Chaloin, Mohammed Habib, Jean-Christophe Peter, Pascal Schneider, Bernard Vray, René E Toes, Rienk Offringa, Cornelis J M Melief, Johan Hoebeke & Gilles Guichard
doi:10.1038/nchembio746
First Paragraph - C: 3: -symmetric peptide scaffolds are functional mimetics of trimeric CD40L | Full Text - C3-symmetric peptide scaffolds are functional mimetics of trimeric CD40L | PDF (636 KB) - C3-symmetric peptide scaffolds are functional mimetics of trimeric CD40L | Supplementary information | Chemical compounds
See also: News and Views by Hymowitz & Ashkenazi
Actin is the primary cellular receptor of bistramide A - pp383 - 388
Alexander V Statsuk, Ruoli Bai, Jeremy L Baryza, Vishal A Verma, Ernest Hamel, Paul A Wender & Sergey A Kozmin
doi:10.1038/nchembio748
First Paragraph - Actin is the primary cellular receptor of bistramide A | Full Text - Actin is the primary cellular receptor of bistramide A | PDF (332 KB) - Actin is the primary cellular receptor of bistramide A | Supplementary information | Chemical compounds
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Analysis of drug-induced effect patterns to link structure and side effects of medicines - pp389 - 397
Anton F Fliri, William T Loging, Peter F Thadeio & Robert A Volkmann
doi:10.1038/nchembio747
Abstract - Analysis of drug-induced effect patterns to link structure and side effects of medicines | Full Text - Analysis of drug-induced effect patterns to link structure and side effects of medicines | PDF (699 KB) - Analysis of drug-induced effect patterns to link structure and side effects of medicines | Supplementary information | Chemical compounds
