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In This Issue

In This Issue pv

doi:10.1038/nchembio1205-v


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Editorial

Coming clean p349

doi:10.1038/nchembio1205-349


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News and Views

Small molecules thwart crash and burn pp351 - 353

Samuel Sidi & A Thomas Look

doi:10.1038/nchembio1205-351

The zebrafish has become a popular model organism to investigate many biological processes, in part owing to the combination of facile genetic manipulation and rapid, external embryonic development. The application of large-scale screening to identify chemical suppressors of a cancer-prone mutant highlights new technology for whole organism–based small-molecule discovery.

See also: Letter by Stern et al.


Toward small-molecule agonists of TNF receptors pp353 - 354

Sarah G Hymowitz & Avi Ashkenazi

doi:10.1038/nchembio1205-353

Development of small-molecule agonists against members of the tumor necrosis factor (TNF) receptor superfamily remains a considerable challenge. Presentation of ligand-derived peptides on a trimeric scaffold may point the way toward development of potent small-molecule agonists against this biologically important protein superfamily.

See also: Letter by Fournel et al.


NO link between calorie restriction and mitochondria pp355 - 356

Leonard Guarente

doi:10.1038/nchembio1205-355

Sir2 is a key regulator in promoting longevity in response to a low-calorie diet. A new role for nitric oxide in promoting mitochondrial synthesis may be the reason why.


Lactate transportation is required for lymphocyte activation pp356 - 357

Stefan Bröer

doi:10.1038/nchembio1205-356

Identification of the monocarboxylate transporter 1 as a target of a new class of immunosuppressants shows that aerobic glycolysis and lactate release are essential for the proliferation of activated lymphocytes.

See also: Letter by Murray et al.


Research Highlights p359

doi:10.1038/nchembio1205-359


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Letters

Small molecules that delay S phase suppress a zebrafish bmyb mutant pp366 - 370

Howard M Stern, Ryan D Murphey, Jennifer L Shepard, James F Amatruda, Christian T Straub, Kathleen L Pfaff, Gerhard Weber, John A Tallarico, Randall W King & Leonard I Zon

doi:10.1038/nchembio749

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See also: News and Views by Sidi & Look


Monocarboxylate transporter MCT1 is a target for immunosuppression pp371 - 376

Clare M Murray, Raymond Hutchinson, John R Bantick, Graham P Belfield, Amanda D Benjamin, Diana Brazma, Robert V Bundick, I David Cook, Robert I Craggs, Susan Edwards, Leslie R Evans, Richard Harrison, Elain Holness, Andrew P Jackson, Clive G Jackson, Lee P Kingston, Matthew W D Perry, Andrew R J Ross, Paul A Rugman, Sasvinder S Sidhu, Michael Sullivan, David A Taylor-Fishwick, P Craig Walker, Yvonne M Whitehead, David J Wilkinson, Andrew Wright & David K Donald

doi:10.1038/nchembio744

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See also: News and Views by Bröer


C3-symmetric peptide scaffolds are functional mimetics of trimeric CD40L pp377 - 382

Sylvie Fournel, Sébastien Wieckowski, Weimin Sun, Nathalie Trouche, Hélène Dumortier, Alberto Bianco, Olivier Chaloin, Mohammed Habib, Jean-Christophe Peter, Pascal Schneider, Bernard Vray, René E Toes, Rienk Offringa, Cornelis J M Melief, Johan Hoebeke & Gilles Guichard

doi:10.1038/nchembio746

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See also: News and Views by Hymowitz & Ashkenazi


Actin is the primary cellular receptor of bistramide A pp383 - 388

Alexander V Statsuk, Ruoli Bai, Jeremy L Baryza, Vishal A Verma, Ernest Hamel, Paul A Wender & Sergey A Kozmin

doi:10.1038/nchembio748

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