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Letter

Nature Chemical Biology 1, 366–370 (1 December 2005) | doi:10.1038/nchembio749

Small molecules that delay S phase suppress a zebrafish bmyb mutant

Howard M Stern , Ryan D Murphey , Jennifer L Shepard , James F Amatruda , Christian T Straub , Kathleen L Pfaff , Gerhard Weber , John A Tallarico , Randall W King & Leonard I Zon

Bmyb is a ubiquitously expressed transcription factor involved in cellular proliferation and cancer. Loss of bmyb function in the zebrafish mutant crash&burn (crb) results in decreased cyclin B1 expression, mitotic arrest and genome instability.