1. Samuel Sidi and A. Thomas Look are in the Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA. e-mail: Thomas_Look@dfci.harvard.edu.

Abstract

The zebrafish has become a popular model organism to investigate many biological processes, in part owing to the combination of facile genetic manipulation and rapid, external embryonic development. The application of large-scale screening to identify chemical suppressors of a cancer-prone mutant highlights new technology for whole organism–based small-molecule discovery.

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