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Letter
Nature Chemical Biology 1, 329–332 (1 November 2005) | doi:10.1038/nchembio738
Evolution of glutamate interactions during binding to a glutamate receptor
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Abstract
Glutamate receptors are the predominant mediators of excitatory synaptic signals in the central nervous system and are important in learning and memory as well as in diverse neuropathologies including epilepsy and ischemia. Their primary function is to receive the chemical signal glutamate (1), which binds to an extracellular domain in the receptor, and convert it into an electrical signal through the formation of cation-permeable transmembrane channels.
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