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Nature Chemical Biology 1, 323 (1 November 2005) | doi:10.1038/nchembio1105-323
Research Highlights
Abstract
Melting the molten globule Although much research has gone into studying protein folding, the difficulties of studying a potentially heterogeneous ensemble of pathways by bulk solution measurements has made it difficult to draw firm conclusions about the pathways involved. Single-molecule measurements offer an approach for watching an individual protein molecule fold; however, previous studies have lacked the resolution to observe folding intermediates.
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