Meeting Report


Nature Chemical Biology 1, 308 - 314 (2005)
doi:10.1038/nchembio1105-308



There is a Corrigendum (February 2006) associated with this Meeting Report.

The emerging biology of the nitrite anion

Mark T Gladwin1, Alan N Schechter2, Daniel B Kim-Shapiro3, Rakesh P Patel4, Neil Hogg5, Sruti Shiva6, Richard O Cannon, III6, Malte Kelm7, David A Wink8, Michael Graham Espey8, Edward H Oldfield9, Ryszard M Pluta9, Bruce A Freeman10, Jack R Lancaster, Jr4, Martin Feelisch11 & Jon O Lundberg12

  1. Mark T. Gladwin is in the Vascular Medicine Branch, National Heart, Lung, and Blood Institute, and the Critical Care Medicine Department, Clinical Center, US National Institutes of Health, Bethesda, Maryland, USA.e-mail: mgladwin@nih.gov
  2. Alan N. Schecter is in the National Institute of Diabetes and Digestive and Kidney Diseases, US National Institutes of Health, Bethesda, Maryland, USA.
  3. Daniel B. Kim-Shapiro is in the Department of Physics, Wake Forest University, North Carolina, USA.
  4. Rakesh Patel and Jack R. Lancaster are at the University of Alabama at Birmingham, Birmingham, Alabama, USA.
  5. Neil Hogg is at the Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
  6. Sruti Shiva is in the Vascular Medicine Branch, and Richard O. Cannon III is in the Cardiovascular Branch, National Heart, Lung, and Blood Institute, US National Institutes of Health, Bethesda, Maryland, USA.
  7. Malte Kelm is at Heinrich-Heine-Universität, Düsseldorf, Germany.
  8. David A. Wink and Michael Graham Espey are at the National Cancer Institute, US National Institutes of Health, Bethesda, Maryland, USA.
  9. Edward H. Oldfield and Ryszard M. Pluta are in the Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, US National Institutes of Health, Bethesda, Maryland, USA.
  10. Bruce A. Freeman is in the Department of Pharmacology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
  11. Martin Feelisch is at Boston University School of Medicine, Boston, Massachusetts, USA.
  12. Jon O. Lundberg is in the Department of Physiology & Pharmacology, Karolinska Institutet, Stockholm, Sweden.

Correspondence to: Mark T Gladwin1


Nitrite has now been proposed to play an important physiological role in signaling, blood flow regulation and hypoxic nitric oxide homeostasis. A recent two-day symposium at the US National Institutes of Health highlighted recent advances in the understanding of nitrite biochemistry, physiology and therapeutics.

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